UVB Radiation Protective Effect of Brown Alga Padina australis: A Potential Cosmeceutical Application of Malaysian Seaweed

Marine natural products are a good source of antioxidants due to the presence wide range bioactive compounds. Accumulating evidence proves potential use seaweed-derived ingredients in skincare products. This study aims evaluate ultraviolet (UV) protective activity ethanol and water extracts Padina australis. As preliminary attempt for this discovery, total phenolic content (TPC) flavonoid (TFC) were measured, followed by vitro antioxidant using 2,2-diphenyl-1-picrylhydrazyl (DPPH) reducing power shed light on its bioactivity. The UVB was examined HaCaT human keratinocyte cells. findings reveal that P. australis extract serves as promising antioxidants, it exhibits stronger activities compared with DPPH assays. also demonstrated higher level (76 mg GAE/g) contents (50 QE/g). Meanwhile, both (400 µg/mL) protected cells from UVB-induced cell damage via promoting viability. Following that, LCMS analysis reveals consists sugar alcohol, polysaccharide, carotenoid, terpenoid fatty acid, whereas contains compounds phenol, terpenoid, alcohol acid amide. In summary, biometabolites derived have diverse functional properties, they could be applied developments cosmeceutical pharmaceutical